College football odds, picks, predictions for Week 4, 2024: Proven model loves Florida State in best bets

SportsLine's advanced computer model has revealed its 2024 Week 4 college football picks

By CBS Sports Staff

Sep 20, 2024 at 11:14 am ET • 3 min read

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The No. 15 Oklahoma Sooners will get their first taste of SEC action on Saturday when they host the No. 6 Tennessee Volunteers for a 7:30 p.m. ET kickoff in Norman. Both teams are unbeaten and can establish themselves as clear-cut College Football Playoff contenders with a victory. Tennessee is a 6.5-point road favorite in the Week 4 college football odds via the SportsLine Consensus, making the Volunteers the first touchdown favorite in Norman since Texas Tech in 1998.

Meanwhile, Deion Sanders and Colorado are 1.5-point home favorite against Baylor according to the latest Week 4 college football lines. So which side should you be backing in Oklahoma vs. Tennessee and Colorado vs. Baylor, and what other Week 4 college football spreads might you be able to take advantage of? Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!

Now, it has turned its attention to the latest college football odds and Week 4 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 4

One of the college football picks the model is high on during Week 4: UCLA (+22.5) stays well within the spread at No. 16 LSU in a 3:30 p.m. ET matchup on Saturday. After grinding out a season-opening 16-13 win in Hawaii for Deshaun Foster's debut, the Bruins were hammered 42-13 by Indiana in their Big Ten opener. However, it hasn't exactly been smooth sailing for LSU so far this season either.

The Tigers opened the season with a loss to USC, beat Nicholls 44-21 and then needed a massive comeback effort to beat South Carolina 36-33 last week, failing to cover the spread in each contest. This line was at +17.5 at open and has been sliding in LSU's direction all week, but the model sees value being created on the road team. It says that the Bruins now cover the spread in nearly 60% of simulations. See the rest of its Week 4 college football picks here.

Another prediction: Florida State (-2.5) finally wins and covers the spread against California in a 7 p.m. ET kickoff on Saturday. Finding value is all about getting the right number, and Florida State's brutal start to the season has created a valuable contrarian spot on Saturday night. The Seminoles have certainly been disappointing through their first three games, but they were 17-point home favorites against Boston College just two weeks ago.

Meanwhile, Cal was a 12-point underdog when it traveled to unranked Auburn earlier this month, so this is a drastic adjustment. The Golden Bears are coming off a sloppy performance against a San Diego State team that was playing without its starting quarterback. They committed 12 penalties for 113 yards in that contest, and it will be difficult for them to go on the road and spring an upset with those kinds of undisciplined mistakes. SportsLine's model has Florida State picking up its first win of the season on Saturday, as the Seminoles are covering the spread in over 60% of simulations. See picks for every other game in Week 4 here.

How to make college football picks for Week 4

The model has also made the call on who wins and covers in every FBS matchup in Week 4, and it's calling for a whopping seven underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which seven underdogs win outright in Week 4? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.