College football odds, picks, top predictions, best bets for Week 7: Proven simulation backs Clemson, Kentucky

SportsLine's advanced computer model has revealed its top Week 7 college football picks

By CBS Sports Staff

Oct 15, 2022 at 11:00 am ET • 4 min read

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The Week 7 college football schedule is loaded with intriguing matchups, including No. 5 Michigan vs. No. 10 Penn State and No. 3 Alabama at No. 6 Tennessee (3:30 p.m. ET, CBS). There are also multiple other ranked vs. ranked matchups on the docket, creating plenty of opportunities to find value in the Week 7 college football lines. Alabama is a 9-point road favorite at Neyland Stadium, despite 65% of the public bets being on Tennessee at Caesars Sportsbook. Should you be backing the Crimson Tide or rolling with the Vols with your Week 7 college football bets?

Michigan is a 7-point home favorite against the Nittany Lions, according to the latest Week 7 college football odds. The Wolverines have won five of their six games by double digits, while Penn State is facing a ranked opponent for the first time this season. Before locking in any Week 7 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 7 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 7

One of the college picks the model is high on in Week 7: No. 4 Clemson (-4.5) cruises to a double-digit win at Florida State on Saturday night. The Seminoles are reeling heading into this matchup, having lost consecutive games against Wake Forest and NC State. Clemson has already beaten both of those teams, making this a terrible scheduling spot for the Seminoles.

Florida State quarterback Jordan Travis completed just 15 of 30 passes for 181 yards and one touchdown last week, while also throwing multiple interceptions in a game for the first time this season. He is facing a Clemson defense that leads the ACC in takeaways and is one of the top defensive teams in college football. The Tigers have been able to control the pace of their games with their rushing attack, which is averaging 4.6 yards per carry.

Clemson has won six consecutive games in this series, including a 45-14 win in its last visit to Tallahassee. SportsLine's model expects that success to continue on Saturday night, as the Tigers are covering the spread in well over 60% of simulations.

Another one of the model's top college football picks: No. 22 Kentucky (+4) keeps things close enough to cover the spread at home when it hosts No. 16 Mississippi State at 7:30 p.m. ET. Much of the narrative on this game revolves around the availability of Wildcats quarterback Will Levis, who missed last week with a foot/ankle injury. However, Kentucky's defense will need to be the difference-maker this week.

Mississippi State's offensive line has held up following an injury to left tackle Kwatrivous Johnson, but Kentucky hasn't had tremendous success getting to opposing quarterbacks this year, and has just nine sacks. Still, the Wildcats have consistently been able to get off of the field on third downs, and have held offenses to just a 31.3% conversion rate. Kentucky has also allowed just three passing touchdowns and picked off five passes while holding opponents to just 6.3 passing yards per attempt this season.

The model predicts that Mississippi State QB Will Rogers will still rack up close to 350 passing yards, but that will be about all the Bulldogs have to show for themselves on the road. While that might be enough to win, it won't be enough to cover, as Kentucky stays within the number more than 50% of the time. See which other teams the model likes here.

How to make college football picks for Week 7

The model has also made the call on who wins and covers in every other FBS matchup in Week 7, and it says a top-15 favorite will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-15 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.