College football odds, lines, picks, bets, predictions for Week 4, 2021: Proven simulation backing LSU, UCLA

SportsLine's advanced computer model has revealed its top Week 4 college football picks and bets

By CBS Sports Staff

Sep 25, 2021 at 8:09 am ET • 3 min read

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Baylor might be off to a 3-0 start this season, but oddsmakers are not expecting the unbeaten run to continue when the Bears host No. 14 Iowa State on Saturday afternoon. The Cyclones are seven-point favorites in the latest Week 4 college football odds at Caesars Sportsbook. Seventh-ranked Texas A&M is a five-point favorite against No. 16 Arkansas in the SEC on CBS matchup during the Week 4 college football schedule. No. 18 Wisconsin is favored by 6.5 points against No. 12 Notre Dame in the other ranked-vs-ranked matchup.

Which Week 4 college football lines deserve your attention? And which college football bets should you be targeting on Saturday? Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 4 college football predictions

One of the top college football picks the model is recommending for Week 4: LSU (-2.5) covers at Mississippi State at noon ET on Saturday. The Tigers are going to have revenge on their mind following a loss to Mississippi State last season. Bulldogs quarterback K.J. Costello threw for an SEC record 623 yards in a 44-34 win. Fortunately for LSU, Costello's collegiate career is over.

The Tigers are coming off a pair of blowout wins over McNeese State and Central Michigan. Their offense, led by quarterback Max Johnson, has shown some improvement. Johnson threw five touchdown passes in the win over Central Michigan. The model has LSU covering this spread in over 60 percent of simulations.

Another one of the college football predictions from the model: No. 24 UCLA (-5) covers at Stanford. The Bruins got off to a nice start this season when they picked up wins over Hawaii and No. 16 LSU, but they slipped up in a loss to Fresno State last week. They are going to be motivated for a bounce-back performance at Stanford on Saturday. UCLA quarterback Dorian Thompson-Robinson has completed 55 percent of his pass attempts and has a 7-to-1 touchdown-to-interception ratio this season.

Stanford has played three straight games away from home to open the season, which could lead to some fatigue entering this contest. The Bruins have covered the spread in six of their last nine games and they are 4-2 ATS in their last six conference matchups. SportsLine's model has UCLA covering this spread in almost 60 percent of simulations.

How to make Week 4 college football picks

The model has also made the call on who wins and covers in every other game on the Week 4 college football schedule, and it's calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past five-plus seasons, and find out.