College football odds, lines, bets, predictions for Week 6, 2021: Computer model picks Michigan, Ole Miss

SportsLine's advanced computer model has revealed its top Week 6 college football picks and bets

By CBS Sports Staff

Oct 9, 2021 at 8:53 am ET • 3 min read

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No. 16 Kentucky is coming off one of its biggest wins in program history, knocking off 10th-ranked Florida at home for the first time since 1986. The Wildcats are also 5-0 for just the fourth time in the last 70 years. They will try to stay unbeaten when they host LSU on Saturday night as part of the Week 6 college football schedule. Kentucky is a three-point favorite in the latest Week 6 college football odds at Caesars Sportsbook.

Elsewhere in the SEC, No. 1 Alabama is -18 at Texas A&M, while No. 2 Georgia is -15 at No. 18 Auburn in the two SEC on CBS matchups on Saturday. Will the Aggies or Tigers be able to spring an upset -- or at least keep it within the spread? And which other Week 6 college football lines around the country should you be targeting in your bets? Before making any Week 6 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 6 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 6 college football predictions

One of the top college football picks the model is recommending for Week 6: No. 17 Ole Miss covers as a six-point favorite against No. 13 Arkansas. The Rebels were unable to compete with top-ranked Alabama last week, falling behind early and never recovering. It was a similar story for Arkansas, which was shut out by second-ranked Georgia. Ole Miss is led by quarterback Matt Corral, the player who currently has the second-shortest Heisman Trophy odds at Caesars.

SportsLine's model is projecting Corral to throw for 256 yards and two touchdowns on Saturday afternoon. The balanced Ole Miss rushing attack is expected to have a big day as well. Arkansas does not have enough firepower to keep up, which is why the Rebels are covering the spread in almost 60 percent of simulations.

Another one of the college football predictions from the model: No. 9 Michigan (-3) covers at Nebraska. The Wolverines went 2-4 during last year's shortened season, putting head coach Jim Harbaugh squarely on the hot seat. They have recovered quite nicely so far, going 5-0 and jumping into the AP Top 10 to open the season. Nebraska has already lost to Illinois, Oklahoma and Michigan State this year.

Michigan played its first road game of the season last week, blowing out Wisconsin in a 38-17 final. SportsLine's model is expecting the Wolverines to average more than 4.5 yards per carry as a team on Saturday night, which will allow them to control the pace of the game. Michigan is covering the spread in over 60 percent of simulations, while the under (50.5) is cashing almost 60 percent of the time.

How to make Week 6 college football picks

The model has also made the call on who wins and covers in every other game on the Week 6 college football schedule, and it's calling for a national title contender to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which national title contender goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,400 in profit over the past five-plus seasons, and find out.