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The No. 25 BYU Cougars will take on the Virginia Cavaliers at 10:15 p.m. ET next Saturday at LaVell Edwards Stadium. BYU is 6-2 overall and 3-1 at home, while Virginia is 6-2 overall and 2-1 on the road. Virginia is 6-2 and BYU is 3-5 against the spread in 2021. Virginia leads the all-time series 3-2.

BYU is favored by 2.5 points in the latest BYU vs. Virginia odds from Caesars Sportsbook, and the over-under is set at 63.5. Before entering any Virginia vs. BYU picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It also enters Week 9 of the 2021 season on a 26-11 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on BYU vs. Virginia and just locked in its coveted picks and CFB predictions. You can head to SportsLine now to see all of the model's CFB picks. Here are several college football odds and betting lines for BYU vs. Virginia:

  • BYU vs. Virginia spread: BYU -2.5
  • BYU vs. Virginia over-under: 64 points
  • BYU vs. Virginia moneyline: BYU -135, Virginia +115

What you need to know about BYU

BYU used a strong second half to defeat Washington State 21-19 last weekend. Running back Tyler Allgeier had a stellar game for BYU as he rushed for 191 yards and two touchdowns on 32 carries.

The Cougars' defense will face an extremely tough test against a Virginia offense that has been held under 500 total yards just once in 2021. On the flip side, the Cavaliers defense has been susceptible all year, which could prove to be a huge advantage for BYU. The Cougars are always tough to beat on their home turf at LaVell Edwards Stadium.

What you need to know about Virginia

Meanwhile, the Cavaliers were able to grind out a solid win over the Georgia Tech Yellow Jackets on Saturday, winning 48-40. QB Brennan Armstrong had a dynamite game for Virginia; he passed for four TDs and 396 yards on 43 attempts in addition to rushing for two TDs and 99 yards. Near the top of the highlight reel was Armstrong's 77-yard TD bomb to WR Dontayvion Wicks in the second quarter.

Virginia head coach Bronco Mendenhall held the same job at BYU from 2005-2015, so it's safe to say winning this game will be important to him. The Cavaliers have one of the premier aerial attacks in the country, averaging 404.6 passing yards per game.

How to make Virginia vs. BYU picks

The model has simulated BYU vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's BYU vs. Virginia pick at SportsLine.

So who wins BYU vs. Virginia? And which side of the spread hits more than 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.