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The No. 7 Alabama Crimson Tide (4-1) will return home following their shocking loss at Vanderbilt when they host the South Carolina Gamecocks (3-2) on Saturday afternoon. Alabama won its first four games of the season to jump to the top of the AP poll, but the Commodores notched their first win over a top-ranked team in school history. The Crimson Tide will try to bounce back against a South Carolina team that is coming off a 27-3 loss to then-No. 12 Ole Miss. The Gamecocks have not gone on the road since picking up a 31-6 win at Kentucky in Week 2. 

Kickoff is set for noon ET on Saturday at Bryant-Denny Stadium. Alabama is favored by 21.5 points in the latest Alabama vs. South Carolina odds, while the over/under is 50.5 points, per SportsLine consensus. Before entering any South Carolina vs. Alabama picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks since inception, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen strong returns.

The model has set its sights on South Carolina vs. Alabama. You can head to SportsLine to see its picks. Here are several college football betting lines for the spreadmoney line and over/under for Alabama vs. South Carolina:

  • Alabama vs. South Carolina spread: Alabama -21.5
  • Alabama vs. South Carolina over/under: 50.5 points
  • Alabama vs. South Carolina money line: Alabama -2000, South Carolina +993
  • Alabama vs. South Carolina picks: See picks here
  • Alabama vs. South Carolina streaming: FuboTV (Try for free)

Why Alabama can cover

Alabama's defense was unable to slow down Vanderbilt quarterback Diego Pavia in last week's loss, but the Crimson Tide should be focused and motivated on Saturday. Their offense was not the issue in that game, as junior quarterback Jalen Milroe completed 19 of 25 passes for 312 yards and a touchdown. Star freshman wide receiver Ryan Williams caught three passes for 82 yards and a score. 

Milroe has now completed 73.4% of his passes for 1,274 yards and 11 touchdowns while rushing 59 times for 283 yards and nine more scores. Junior running back Jam Miller leads Alabama's rushing attack with 318 yards and five touchdowns on 39 carries, averaging 8.2 yards per attempt. The Crimson Tide are 19-8-1 against the spread as home favorites over the past five seasons. See which team to pick here. 

Why South Carolina can cover

South Carolina is coming off a 27-3 loss to Ole Miss, but the Gamecocks were much more impressive in their first four games of the season. They went on the road and blew out Kentucky as 9.5-point underdogs in their lone conference road game, as freshman quarterback LaNorris Sellers completed 11 of 15 passes with two touchdowns. He also helped South Carolina cover the spread as a 6.5-point home underdog in a 36-33 loss to then-No. 16 LSU the following week. 

The Gamecocks covered the spread as 25-point favorites in their 50-7 win over Akron prior to the Ole Miss loss. Sellers has 548 passing yards, 207 rushing yards and five total touchdowns this season. South Carolina has covered the spread in four of the last five meetings between these teams. See which team to pick here. 

How to make Alabama vs. South Carolina picks

The model has simulated South Carolina vs. Alabama 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Alabama vs. South Carolina, and which side of the spread is hitting over 50% of the time? Visit SportsLine now to see which side of the South Carolina vs. Alabama spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.