After breezy wins over Akron and Western Michigan to start the season, the Ohio State Buckeyes sit at No. 3 in the AP Top 25 entering a Week 3 matchup against Marshall. With a Big Ten opener against Michigan State looming, Ryan Day will be hoping to keep his College Football Playoff contender focused for a Marshall squad that has been bowl eligible the last three seasons under Charles Huff. The Buckeyes are a 39.5-point home favorite over the Thundering Herd according to the latest Week 4 college football odds via SportsLine consensus.
Meanwhile, rival Michigan has a much tougher test on Saturday, with the No. 18 Wolverines hosting the No. 11 USC Trojans for a Big Ten on CBS battle at 3:30 p.m. ET. USC is a 4.5-point road favorite in the Week 4 college football lines for its first-ever Big Ten matchup. Before locking in any Week 4 college football picks, be sure to see the top Week 4 college football expert picks, predictions and best bets from Thomas Casale.
A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.
Now, he has turned his attention to the Week 4 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.
Top Week 4 college football expert predictions
One of Casale's top Week 4 college football picks: He is backing LSU (-21.5) to cover against UCLA on Saturday at 3:30 p.m. ET. Brian Kelly's seat was looking toasty after falling behind 17-0 against South Carolina last week and it could still be warm, but the Tigers were able to battle back to earn a 36-33 win on the road in the SEC last week and their College Football Playoff hopes are still very much alive entering Week 4.
The Tigers are ranked No. 16 in the AP Top 25 and LSU quarterback Garrett Nussmeier leads the SEC with 10 touchdown passes over his first three games. Meanwhile, UCLA was just thrashed 42-13 at home against Indiana in its Big Ten opener with Hoosiers QB Kurtis Rourke completing 75.8% of his passes for 307 yards and four touchdowns in the victory.
The Bruins will have their work cut out contending with Nussmeier and wide receiver Kyren Lacy, who looks like the latest in a long line of great LSU receivers. Lacy has five touchdown catches already this season and Casale is expecting a breakthrough performance for LSU offensively to help cover the sizable spread at home. See what other picks Casale likes at SportsLine.
How to make Week 4 college football picks
Casale has also found two other college football picks he loves, including backing an overlooked team that "excels in the underdog role." You can only see his picks at SportsLine.
What are the best bets for Week 4 of college football, and which underdog should you be all over? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.
