The Georgia Tech Yellow Jackets opened their season with an upset of Florida State in Ireland and after adding wins over Georgia State and VMI but losing on the road to Syracuse, the Yellow Jackets will get another crack at a ranked ACC opponent on Saturday. No. 19 Louisville will host Georgia Tech on Saturday and the latest Week 4 college football odds list the Cardinals as 10.5-point favorites. Can Brent Key's squad score another upset victory, or will Louisville begin its march towards the ACC Championship Game and the College Football Playoff with a win?
Other notable Week 4 matchups on Saturday include Illinois at Nebraska (-7.5), USC at Michigan (+5.5), Utah at Oklahoma State (+2.5), and Tennessee at Oklahoma (+7). So how should you be handling all those marquee matchups on the Week 4 college football schedule, and what other Week 4 college football lines should you be targeting this week in your parlays? Before locking in any Week 4 college football picks, be sure to see the top Week 4 college football expert picks, predictions and best bets from Thomas Casale.
A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.
Now, he has turned his attention to the Week 4 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.
Top Week 4 college football expert predictions
One of Casale's top Week 4 college football picks: He is backing LSU (-24.5) against UCLA on Saturday. Chip Kelly led the Bruins to 25 victories over the last three seasons but he made the puzzling decision to leave the program to become the Ohio State offensive coordinator just as UCLA was about to make the leap to the Big Ten.
Enter DeShaun Foster, who rushed for 3,049 yards and 39 touchdowns in four years with the Bruins. Foster was a UCLA assistant from 2017-2023 but he hasn't been able to pick up where Kelly left off. UCLA is averaging just 6.7 yards per pass attempt this season and 3.6 yards per rush and they'll likely have trouble keeping pace with the LSU offense on Saturday.
"UCLA is one of the worst Power 4 teams in the country this season," Casale told SportsLine. "The Bruins were lucky to beat Hawaii 16-13 and then got blasted at home by Indiana, 42-13. That score would have been even worse if Indiana didn't commit 14 penalties." See what other picks Casale likes at SportsLine.
How to make Week 4 college football picks
Casale has also found two other college football picks he loves, including backing an overlooked team that "excels in the underdog role." You can only see his picks at SportsLine.
What are the best bets for Week 4 of college football, and which underdog should you be all over? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.
