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The Georgia Tech Yellow Jackets moved up to No. 23 in the latest AP Top 25 after wins against Florida State and Georgia State in the first two weeks of the season. Now they'll move back into ACC play with a matchup against the Syracuse Orange on Saturday in Upstate New York. The Yellow Jackets are 3-point favorites according to the latest Week 2 college football odds via SportsLine consensus, and it will be their first true road game of the season after playing FSU on neutral turf in Ireland.

Meanwhile, the biggest rivalry game on the Week 2 college football schedule will be No. 21 Iowa battling Iowa State for the Cy-Hawk Trophy. The Hawkeyes are 2.5-point favorites in the Week 2 college football lines, and the teams have split their last four meetings against the spread. Before locking in any Week 2 college football picks, be sure to see the top Week 2 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.

Now, he has turned his attention to the Week 2 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 2 college football expert predictions

One of Casale's top Week 2 college football picks: He's backing Auburn at -12.5 against Cal at 3:30 p.m. ET on Saturday. It's Auburn's turn to host after beating Cal in Berkeley last season 14-10. Both teams struggled to find footing offensively, combining for 503 yards of total offense. However, Auburn certainly looks more comfortable and better-equipped for Hugh Freeze's offense in Year Two.

Payton Thorne and Jarquez Hunter are both back and the receiving room has been completely reworked. Three true freshman wide receivers (5-star Cam Coleman, 4-star Malcolm Simmons and 4-star Perry Thompson) all scored touchdowns last week, as did Penn State transfer Keandre Lambert-Smith. There were several upgrades on the defensive side of the ball too and that's a big reason why Casale likes Auburn big.

"Freeze raved about his defense all summer and I think that's the story here. Cal quarterback Fernando Mendoza threw for just 158 yards in the opener against UC Davis," Casale told SportsLine. "He will need to have a big game because I don't see the Golden Bears running the ball consistently on Auburn's defense." See what other picks Casale likes at SportsLine

How to make Week 2 college football picks 

Casale has also found two other college football picks he loves, including going Over in a game that "looks like a shootout." You can only see his picks at SportsLine.

What are the best bets for Week 2 of college football, and which team has a big edge in the trenches? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.