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The Xavier Musketeers and the Butler Bulldogs are set to square off in a 2022 Big East Tournament matchup at 4:30 p.m. ET on Wednesday at Madison Square Garden. Butler is 13-18 overall, while the Musketeers are 18-12. Xavier swept the regular-season series between these teams, but the second game was decided by just two points. 

The Musketeers are favored by 6.5-points in the latest Xavier vs. Butler odds from Caesars Sportsbook, while the over-under is set at 131.5. Before entering any Butler vs. Xavier picks, you'll want to see the college basketball predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,600 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Xavier vs. Butler. You can head to SportsLine to see its picks. Here are several college basketball odds for Xavier vs. Butler:

  • Xavier vs. Butler spread: Xavier -6.5
  • Xavier vs. Butler over-under: 131.5 points

What you need to know about Xavier

Xavier cannot afford another bad loss on its NCAA Tournament resume, so it will be motivated to take care of business on Wednesday afternoon. The Musketeers went on a five-game losing streak in February, but they were able to get back on track with a 97-75 win over Georgetown on Saturday. They have already picked up a pair of wins over Butler this season, including an 87-72 victory on the road in early January. 

Junior forward Jack Nunge leads Xavier with 13.1 points and 7.5 rebounds per game, while junior forward Paul Scruggs is scoring 11.9 points. Sophomore guard Colby Jones (11.0) and senior guard Nate Johnson (10.4) are both scoring in double figures as well. The Musketeers have only covered the spread once in their last six games. 

What you need to know about Butler

Butler will need to win the Big East Tournament if it wants to make an appearance in the NCAA Tournament next week. The Bulldogs closed the regular season on a five-game losing streak, including a 78-59 loss to Villanova in their finale. They were able to play a close game at Xavier in early February, losing by just two points as 11.5-point underdogs. 

Sophomore guard Chuck Harris leads a balanced Butler offense with 10.7 points per game, while senior guard Bo Hodges is averaging 10.4 points and 6.5 rebounds. Senior guard Jair Bolden, who has not played since Feb. 18 due to a back injury, is questionable for this game. The Bulldogs have covered the spread in six of their last eight contests. 

How to make Xavier vs. Butler picks

The model has simulated Xavier vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Butler vs. Xavier? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.