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The Duke Blue Devils will look to continue their home dominance when they face the Notre Dame Fighting Irish in a key ACC matchup on Tuesday. The Blue Devils (7-7, 5-5), who tied for second in the ACC with Louisville and Virginia at 15-5 and were 25-6 overall in 2019-20, are 21-5 at home over the past two seasons. The Fighting Irish (7-10, 4-7), who tied for sixth in the conference with Syracuse and NC State at 10-10 and were 20-12 overall a year ago, have struggled on the road and are 7-12 away from home since the beginning of 2019-20. Notre Dame has had five games canceled or postponed by COVID-19 safety guidelines, while Duke has had two games postponed.

The game from Cameron Indoor Stadium in Durham, N.C., is scheduled to begin at 4:30 p.m. ET. The Blue Devils are 7.5-point favorites in the latest Duke vs. Notre Dame odds from William Hill Sportsbook, down 1.5 points from the opening line. The over-under for total points scored is set at 147, down two points from the opener. Before making any Notre Dame vs. Duke picks, check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Notre Dame. You can head to SportsLine to see its picks. Here are several college basketball odds and trends for Notre Dame vs. Duke:

  • Duke vs. Notre Dame spread: Duke -7.5
  • Duke vs. Notre Dame over-under: 147 points
  • Duke vs. Notre Dame money line: Duke -340; Notre Dame +270
  • ND: Senior forward Juwan Durham is hitting 65 percent of his field goals over the past seven games
  • DU: Senior guard Jordan Goldwire leads the ACC in assist-to-turnover ratio at plus-2.6

Why Duke can cover 

Freshman forward Jalen Johnson is off to a fast start to his collegiate career and is third on the team with a 12.3 points-per-game average. Johnson has reached double figures in six of 11 games, including a 24-point effort at Pittsburgh on Jan. 19. He logged 33 minutes of action in that game, grabbing 16 rebounds, dishing out seven assists, blocking four shots and registering two steals. It marked his second career double-double after posting 19 points and 19 rebounds in the season-opener against Coppin State.

Another newcomer making a huge impression is freshman guard Jeremy Roach, who averages 9.3 points and 2.8 assists per game. He has reached double figures in eight games, including a 16-point performance against North Carolina on Saturday. In that game, he set career highs for steals (3) and made field goals (7). He had 14 points in the first meeting at Notre Dame.

Why Notre Dame can cover

The Fighting Irish have five players who average 9.7 points or better per game, including junior forward Nate Laszewski who leads Notre Dame in scoring at 15.5 points and rebounds at 7.8 per game. He is connecting on 64.3 percent of his shots from the floor, including 52.5 percent from 3-point range. Laszewski led the Irish with 27 points on 11 of 13 shooting with four 3-pointers at Georgia Tech on Saturday. It was his team-high fourth 20-point game this season. He has reached double figures 13 times this season and has two double-doubles.

Also powering Notre Dame is junior guard Prentiss Hubb, who is averaging 14.5 points, 5.9 assists and 3.2 rebounds per game. He has registered 15 steals on the season. He recorded his second consecutive double-double at Georgia Tech, scoring 15 points with 10 assists. For his career, Hubb has started 77 of 82 games and is averaging 11 points and 2.8 rebounds per game.

How to make Notre Dame vs. Duke picks

The model is leaning over on the total, projecting both teams combine for 151 points. It has also generated an against-the-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Duke? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.