In a 2021 NCAA Tournament full of upsets, the undefeated No. 1-seed Gonzaga Bulldogs have delivered as expected, covering as 33-point favorites in the first round against Hartford and covering against Oklahoma as 15.5-point favorites in the second round. Now, the Bulldogs will put their 29-0 record on the line against the No. 5-seed Creighton Bluejays in a Sweet 16 matchup in the 2021 NCAA bracket. Gonzaga is favored by 13.5 in the latest 2021 March Madness odds from William Hill Sportsbook.

The Michigan Wolverines also earned a No. 1 seed in the 2021 March Madness bracket after winning the regular-season Big Ten title and are the only remaining team from the conference. Michigan is a 2.5-point favorite over No. 4 Florida State in the latest 2021 NCAA Tournament lines. Before locking in any college basketball picks, be sure to see the 2021 NCAA Tournament predictions from SportsLine's proven computer model. 

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen massive returns.

This same model produced brackets that beat nearly 90 percent of all CBS Sports brackets one year after finishing in the top five percent. The model also nailed 14 teams in the Sweet 16 last time, and has called 15 of the 26 first-round upsets by double-digit seeds the last four tournaments. In a topsy-turvy 2021 NCAA Tournament bracket, the model entered the Sweet 16 with all of its Final Four teams intact. 

Now, the model has locked in on the latest 2021 NCAA Tournament lines and released point-spread picks and over-under total selections for every Sweet 16 matchup. You can see those selections at SportsLine.

2021 NCAA Tournament Sweet 16 predictions

After barely making it into the 2021 NCAA Tournament bracket as a No. 11 seed, the Syracuse Orange have shocked many by defeating San Diego State and West Virginia on the way to the 2021 NCAA Tournament Sweet 16. Now, they'll take on a Houston Cougars defense that could challenge the red-hot Buddy Boeheim. The coach's son has averaged 28.3 points per game since the ACC Tournament started, but his Orange are six-point underdogs against a Houston defense that led the nation in effective field goal percentage allowed (43.1).

In the South Region, No. 1 seed Baylor will take on the No. 5 seed Villanova for a chance to play in the regional final. The Wildcats are without guard Collin Gillespie after he tore his MCL late in the season, but sophomore forward Jeremiah Robinson-Earl has taken it upon himself to pick up the slack in his absence. Robinson-Early is averaging 20.0 points, 8.5 rebounds and 6.0 assists in his first two tournament games, but he'll have to continue to produce at that level against Baylor's sensational guard trio of Jared Butler, MaCio Teague and Davion Mitchell. The Bears are favored by seven in the latest college basketball odds.

Here's how SportsLine's model sees the 2021 March Madness Sweet 16 bracket playing out straight-up, and you can visit SportsLine now to get 2021 NCAA Tournament spread picks for every game.

Loyola Chicago beats Oregon State -- One side of the spread hits 50 percent of the time. See that pick at SportsLine.

Baylor beats Villanova -- One side of that spread hits 55 percent of the time. See that pick at SportsLine.

Arkansas beats Oral Roberts -- One side of that spread hits 56 percent of the time. See that pick at SportsLine. 

Houston beats Syracuse -- One side of that spread hits 52 percent of the time. See that pick at SportsLine.

Gonzaga beats Creighton -- One side of that spread hits 59 percent of the time. See that pick at SportsLine.

Michigan beats Florida State -- One side of that spread 50 percent of the time. See that pick at SportsLine.

Alabama beats UCLA -- One side of that spread hits 55 percent of the time. See that pick at SportsLine.

Oregon beats USC -- One side of that spread hits 57 percent of the time. See that pick at SportsLine. 

How to make 2021 NCAA Tournament picks

The model has made the call on which team covers in each Sweet 16 game. It says UCLA (+5.5) stays within the spread against Alabama. It says there's a No. 1 seed that gets a massive scare. You can only get spread and total picks for every 2021 NCAA Tournament game at SportsLine.

So what 2021 NCAA Tournament first-round spread picks can you make with confidence? And which No. 1 seed gets a huge scare? Check out the college basketball odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned $2,200 in profit over the past four-plus seasons, and find out.

2021 NCAA Tournament Sweet 16 odds, schedule

Saturday, March 27

Loyola Chicago vs. Oregon State (+6.5, 125.5)
Baylor vs. Villanova (+6.5, 139)
Arkansas vs. Oral Roberts (+11, 159)
Houston vs. Syracuse (+6, 140)

Sunday, March 28

Gonzaga vs. Creighton (+13.5, 158.5)
Michigan vs. Florida State (+3, 144.5)
Alabama vs. UCLA (+5.5, 142.5)
USC vs. Oregon (+1, 139)