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A 2024 NCAA Tournament second-round matchup on Saturday will see the No. 11 Oregon Ducks facing the No. 3 Creighton Bluejays. Creighton (24-9) entered March Madness 2024 ranked 11th in the Top 25 AP Poll after a season in which it finished second in the Big East. As for Oregon (24-11), it's playing its best ball as of late, winning five straight including the Pac-12 Tournament. Both teams are coming off double-digit victories in the first round on Thursday. These programs last met in the 2011 CBI Finals, in which Oregon won the best-of-three series 2-1.

Tipoff is at 9:40 p.m. ET from PPG Paints Arena in Pittsburgh. Oregon is 5-3 straight-up in neutral-site games, while Creighton is 2-3. The latest Oregon vs. Creighton odds via SportsLine consensus have the Bluejays as 4-point favorites. The over/under is 146. Before making any Creighton vs. Oregon picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven model

The model simulates every Division I college basketball game 10,000 times. It enters the 2024 NCAA tournament on a 148-106 roll on all top-rated college basketball picks dating back to last season, returning more than $1,700 for $100 players. It also has a strong 29-19 (+810) record on top-rated spread picks this season. Anyone following has seen huge returns.

Now, the model has set its sights on Creighton vs. Oregon. You can head to SportsLine now to see its picks. Here are several college basketball odds and trends for Oregon vs. Creighton:

  • Creighton vs. Oregon spread: Bluejays -4
  • Creighton vs. Oregon over/under: 146 points
  • Creighton vs. Oregon money line: Bluejays -186, Ducks +155
  • CREI: The Bluejays are 10-5 ATS when favored away from home
  • ORE: The Over is 7-3 in Ducks' games when they are the underdog
  • Creighton vs. Oregon picks: See picks at SportsLine

Why Creighton can cover 

Senior center Ryan Kalkbrenner is a two-way force who has been an anchor for Creighton all year. The 7-footer had 23 points and eight rebounds in Thursday's win over Akron while also blocking three shots. Kalkbrenner's 3.0 blocks per game rank second in all of the NCAA, and he can also step back onto the perimeter as he drained his lone 3-point attempt on Thursday. For the season, the three-time Big East Defensive Player of the Year is averaging 17.3 points, 7.4 rebounds and shoots 65% from the field.

For as productive as Kalkbrenner is, he ranks just third on the team in scoring, which shows the offensive potential of the Bluejays. Baylor Scheierman is an All-Big East first-team selection as he leads Creighton in both points (18.3) and rebounds (9.1). He's logged four double-doubles over his last five games and is shooting a blistering 45.7% on 3-point attempts over this stretch. Meanwhile, junior Trey Alexander puts up 17.6 points per game, and his game travels, as he's averaging 19 points over his last eight games away from home. See which team to pick at SportsLine.

Why Oregon can cover

You can throw many of the season statistics out of the window when it comes to Oregon as it played roughly 40% of its season without its best player in N'Faly Dante. The 6-foot-11 center dominates on both ends of the court, averaging 16.5 points on 70.5% shooting while also contributing 8.7 rebounds, 1.9 blocks and 1.7 steals. He was the Pac-12 Tournament MOP and should present a problem for a Creighton defense which allows the seventh-most made 2-pointers per game in the nation.

The Ducks also have an experienced head coach in Dana Altman, who is very familiar with seeing a second weekend of March Madness. He's made six Sweet 16s at Oregon, and just four other coaches in all of Division I have more Sweet 16 appearances with their current school. Oregon has made it to at least the Sweet 16 in each of its last four NCAA Tournament appearances, and no Pac-12 program has more March Madness victories than Oregon's 15 since 2013. See which team to pick at SportsLine

How to make Oregon vs. Creighton picks

The model is leaning Over on the total, projecting the teams to combine for 151 points. It also says one side of the spread hits over 60% of the time. You can only see the pick at SportsLine.

So who wins Creighton vs. Oregon, and which side of the spread hits over 60% of the time? Visit SportsLine right now to see which side of the Oregon vs. Creighton spread you need to jump on, all from the computer model that is 29-19 on top-rated college basketball spread picks this season.